Prof. FRANCO SERVADEI

TRAUMATIC BRAIN INJURY

Servadei F, Picetti E. Intracranial Pressure Monitoring and Outcome in Traumatic Brain Injury: The Probe Does Matter? World Neurosurg. 2015 Feb 7. pii:S1878-8750(15)00053-4. doi: 10.1016/j.wneu.2015.01.031. [Epub ahead of print] PubMed PMID: 25659804.

Servadei F, Picetti E. Traumatic subarachnoid hemorrhage. World Neurosurg. 2014 Nov;82(5):e597-8. doi 10.1016/j.wneu.2014.08.034. Epub 2014 Aug 19. PubMed PMID: 25150207.

Stocchetti N, Picetti E, Berardino M, Buki A, Chesnut RM, Fountas KN, Horn P, Hutchinson PJ, Iaccarino C, Kolias AG, Koskinen LO, Latronico N, Maas AI, Payen JF, Rosenthal G, Sahuquillo J, Signoretti S, Soustiel JF, Servadei F. Clinical applications of intracranial pressure monitoring in traumatic brain injury : report of the Milan consensus conference. Acta Neurochir (Wien). 2014 Aug;156(8):1615-22. doi: 10.1007/s00701-014-2127-4. Epub 2014 May 22. PubMed PMID: 24849391.

Picetti E, De Angelis A, Villani F, Antonini MV, Rossi I, Servadei F, Caspani ML. Intravenous paracetamol for fever control in acute brain injury patients: cerebral and hemodynamic effects. Acta Neurochir (Wien). 2014 Oct;156(10):1953-9; discussion 1959. doi: 10.1007/s00701-014-2129-2. Epub 2014 May 17. PubMed PMID: 24838770.

Kolias AG, Hutchinson PJ, Menon DK, Manley GT, Gallagher CN, Servadei F. Decompressive craniectomy for acute subdural hematomas. J Neurosurg. 2014 May;120(5):1247-9; author reply 1249. doi: 10.3171/2013.12.JNS132735. Epub 2014 Mar 21. PubMed PMID: 24655100.

Iaccarino C, Schiavi P, Picetti E, Goldoni M, Cerasti D, Caspani M, Servadei F. Patients with brain contusions: predictors of outcome and relationship between radiological and clinical evolution. J Neurosurg. 2014 Apr;120(4):908-18. doi: 10.3171/2013.12.JNS131090. Epub 2014 Feb 7. PubMed PMID: 24506250.

Fabbri A, Servadei F, Marchesini G, Bronzoni C, Montesi D, Arietta L; Società Italiana di Medicina d’Emergenza Urgenza Study Group. Antiplatelet therapy and the outcome of subjects with intracranial injury: the Italian SIMEU study. Crit Care. 2013 Mar 21;17(2):R53. doi: 10.1186/cc12575. PubMed PMID: 23514619; PubMed Central PMCID: PMC3733424.

Schiavi P, Iaccarino C, Compagnone C, Servadei F. Blood-derived biochemical markers and early clinical trends after severe traumatic brain injury: utility or futility? World Neurosurg. 2014 Jan;81(1):59-61. doi: 10.1016/j.wneu.2013.03.021. Epub 2013 Mar 15. PubMed PMID: 23507300.

Schiavi P, Picetti E, Donelli V, Servadei F. Diagnosis and postoperative monitoring of a traumatic carotid-cavernous fistula by jugular venous oximetry: case report and literature review. Acta Neurochir (Wien). 2013 Jul;155(7):1341-2. doi: 10.1007/s00701-013-1676-2. Epub 2013 Mar 14. Review. PubMed PMID: 23494138.

Picetti E, Antonini MV, Lucchetti MC, Pucciarelli S, Valente A, Rossi I, Schiavi P, Servadei F, Caspani ML, Mergoni M. Intra-hospital transport of brain-injured patients: a prospective, observational study. Neurocrit Care. 2013 Jun;18(3):298-304. doi: 10.1007/s12028-012-9802-1. PubMed PMID: 23208448.

Iaccarino C, Schiavi P, Servadei F. Decompressive craniectomies: time to discuss not the DECRA study but the comments to the DECRA study. World Neurosurg. 2013 Jan;79(1):78-9. doi: 10.1016/j.wneu.2012.10.061. Epub 2012 Oct 27. PubMed PMID: 23111210.

Schiavi P, Laccarino C, Servadei F. The value of the calcium binding protein S100 in the management of patients with traumatic brain injury. Acta Biomed. 2012 Apr;83(1):5-20. Review. PubMed PMID: 22978053.

Tagliaferri F, Zani G, Iaccarino C, Ferro S, Ridolfi L, Basaglia N, Hutchinson P, Servadei F. Decompressive craniectomies, facts and fiction: a retrospective analysis of 526 cases. Acta Neurochir (Wien). 2012 May;154(5):919-26. doi: 10.1007/s00701-012-1318-0. Epub 2012 Mar 9. PubMed PMID: 22402877.

Servadei F. Clinical value of decompressive craniectomy. N Engl J Med. 2011 Apr 21;364(16):1558-9. doi: 10.1056/NEJMe1102998. Epub 2011 Mar 25. PubMed PMID: 21434844.

Fabbri A, Servadei F, Marchesini G, Stein SC, Vandelli A. Predicting intracranial lesions by antiplatelet agents in subjects with mild head injury. J Neurol Neurosurg Psychiatry. 2010 Nov;81(11):1275-9. doi: 10.1136/jnnp.2009.197467. Epub 2010 Jul 18. PubMed PMID: 20643657.

Fabbri A, Servadei F, Marchesini G, Raggi A, Vandelli A. Analysis of different decision aids for clinical use in pediatric head injury in an emergency department of a general hospital. J Trauma. 2011 May;70(5):E79-83. doi: 10.1097/TA.0b013e3181d4885a. PubMed PMID: 20495492.

Fabbri A, Servadei F, Marchesini G, Negro A, Vandelli A. The changing face of mild head injury: temporal trends and patterns in adolescents and adults from 1997 to 2008. Injury. 2010 Sep;41(9):913-7. doi: 10.1016/j.injury.2010.03.002. Epub 2010 Apr 2. PubMed PMID: 20362983.

Compagnone C, d’Avella D, Servadei F, Angileri FF, Brambilla G, Conti C, Cristofori L, Delfini R, Denaro L, Ducati A, Gaini SM, Stefini R, Tomei G, Tagliaferri F, Trincia G, Tomasello F. Patients with moderate head injury: a prospective multicenter study of 315 patients. Neurosurgery. 2009 Apr;64(4):690-6; discussion 696-7. doi: 10.1227/01.NEU.0000340796.18738.F7. PubMed PMID: 19197220.

BRAIN TUMORS

Iaccarino C, Orlandi E, Ruggeri F, Nicoli D, Torricelli F, Maggi M, Cerasti D, Pisanello A, Pedrazzi G, Froio E, Crafa P, D’Abbiero N, Michiara M, Ghadirpour R, Servadei F. Prognostic value of MGMT promoter status in non-resectable glioblastoma after adjuvant therapy. Clin Neurol Neurosurg. 2015 May;132:1-8. doi: 10.1016/j.clineuro.2015.01.029. Epub 2015 Feb 7. PubMed PMID: 25723791.

Visani M, de Biase D, Marucci G, Cerasoli S, Nigrisoli E, Bacchi Reggiani ML, Albani F, Baruzzi A, Pession A; PERNO study group. Expression of 19 microRNAs in glioblastoma and comparison with other brain neoplasia of grades I-III. Mol Oncol. 2014 Mar;8(2):417-30. doi: 10.1016/j.molonc.2013.12.010. Epub 2013 Dec 24. PubMed PMID: 24412053.

Michelucci R, Pasini E, Meletti S, Fallica E, Rizzi R, Florindo I, Chiari A, Monetti C, Cremonini AM, Forlivesi S, Albani F, Baruzzi A; PERNO Study Group. Epilepsy in primary cerebral tumors: the characteristics of epilepsy at the onset (results from the PERNO study–Project of Emilia Romagna Region on Neuro-Oncology). Epilepsia. 2013 Oct;54 Suppl 7:86-91. doi: 10.1111/epi.12314. Review. PubMed PMID: 24099060.

Visani M, de Biase D, Marucci G, Taccioli C, Baruzzi A, Pession A; PERNO Study Group. Definition of miRNAs expression profile in glioblastoma samples: the relevance of non-neoplastic brain reference. PLoS One. 2013;8(1):e55314. doi: 10.1371/journal.pone.0055314. Epub 2013 Jan 29. PubMed PMID: 23383149; PubMed Central PMCID: PMC3558478.

Iaccarino C, Schiavi P, Crafa P, Bronzoni C, Ramponi V, Mantenuto G, Cavanna L, Servadei F. Primary dural lymphoma mimicking a chronic epidural hematoma. Differential diagnosis of two rare conditions. Clin Neurol Neurosurg. 2013 Aug;115(8):1510-3. doi: 10.1016/j.clineuro.2012.12.013. Epub 2013 Jan 3. PubMed PMID: 23290421.

de Biase D, Visani M, Morandi L, Marucci G, Taccioli C, Cerasoli S, Baruzzi A, Pession A; PERNO Study Group. miRNAs expression analysis in paired fresh/frozen and dissected formalin fixed and paraffin embedded glioblastoma using real-time pCR. PLoS One. 2012;7(4):e35596. doi: 10.1371/journal.pone.0035596. Epub 2012 Apr 18. PubMed PMID: 22530056; PubMed Central PMCID: PMC3329457.

Chibbaro S, Di Rocco F, Makiese O, Reiss A, Poczos P, Mirone G, Servadei F, George B, Crafa P, Polivka M, Romano A. Neuroendoscopic management of posterior third ventricle and pineal region tumors: technique, limitatioN, and possible complication avoidance. Neurosurg Rev. 2012 Jul;35(3):331-38; discussion 338-40. doi: 10.1007/s10143-011-0370-1. Epub 2012 Jan 19. PubMed PMID: 22258494.

Iaccarino I, Nicoli D, Serra S, Froio E, Pisanello A, De Berti G, Ghadirpour R, Marcello N, Servadei F, Carinci F. Detection of IDH1 mutations and the status of MGMT promoter on intraoperative fresh tissue section from frameless neuronavigation needle biopsy. Analysis on 17 patients with brain glial tumor ineligible for craniotomy and tumor resection. Int J Immunopathol Pharmacol. 2011 Apr-Jun;24(2 Suppl):45-50. PubMed PMID: 21781445

Iaccarino C, Nicoli D, Serra S, Froio E, Pisanello A, De Berti G, Ghadirpour R, Marcello N, Servadei F, Carinci F. Analysis of MGMT promoter methylation status on intraoperative fresh tissue section from frameless neuronavigation needle biopsy of 25 patients with brain tumor. Int J Immunopathol Pharmacol. 2011 Apr-Jun;24(2 Suppl):37-43. PubMed PMID: 21781444.

Romano A, Chibbaro S, Marsella M, Oretti G, Spiriev T, Iaccarino C, Servadei F. Combined endoscopic transsphenoidal-transventricular approach for resection of a giant pituitary macroadenoma. World Neurosurg. 2010 Jul;74(1):161-4. doi: 10.1016/j.wneu.2010.02.024. PubMed PMID: 21300008.

Servadei F, Romano A, Ferri A, Magri AS, Sesenna E. Giant trigeminal schwannoma with parapharyngeal extension: report of a case. J Craniomaxillofac Surg. 2012 Jan;40(1):e15-8. doi: 10.1016/j.jcms.2010.11.012. Epub 2010 Dec 30. PubMed PMID: 21195625.

Zuccoli G, Marcello N, Pisanello A, Servadei F, Vaccaro S, Mukherjee P, Seyfried TN. Metabolic management of glioblastoma multiforme using standard therapy together with a restricted ketogenic diet: Case Report. Nutr Metab (Lond). 2010 Apr 22;7:33. doi: 10.1186/1743-7075-7-33. PubMed PMID: 20412570; PubMed Central PMCID: PMC2874558.

Iaccarino C, Nicoli D, Gallo C, Nasi D, Pisanello A, De Berti G, Ghadirpour R, Marcello N, Servadei F. Analysis of MGMT promoter methylation status on intraoperative fresh tissue section from frameless neuronavigation needle biopsy: a preliminary study of ten patients. Acta Neurochir (Wien). 2010 Jul;152(7):1189-96. doi: 10.1007/s00701-010-0639-0. Epub 2010 Mar 31. PubMed PMID: 20354736.

SPINE

Ghadirpour R, Nasi D, Iaccarino C, Giraldi D, Sabadini R, Motti L, Sala F, Servadei F. Intraoperative neurophysiological monitoring for intradural extramedullary tumors: why not? Clin Neurol Neurosurg. 2015 Mar;130:140-9. doi: 10.1016/j.clineuro.2015.01.007. Epub 2015 Jan 12. PubMed PMID: 25618840.

Ghadirpour R, Nasi D, Benedetti B, Zedde ML, Iaccarino C, Malferrari G, Servadei F. Delayed cervical epidural hematoma after intravenous thrombolysis for acute ischemic stroke: case report and review of literature. Clin Neurol Neurosurg. 2014 Jul;122:50-3. doi: 10.1016/j.clineuro.2014.04.005. Epub 2014 Apr 18. Review. PubMed PMID: 24908216.

De Berti G, Maggi M, Conigliaro R, Levrini G, Salzano S, Ghadirpour R, Servadei F. Administration of conscious sedation by a neuroradiology team during percutaneous vertebroplasty and spinal biopsy procedures. Neuroradiology. 2012 Mar;54(3):231-7. doi: 10.1007/s00234-011-0857-z. Epub 2011 Apr 8. PubMed PMID: 21476021

OTHER

Servadei F, Iaccarino C. The therapeutic cranioplasty still needs an ideal material and surgical timing. World Neurosurg. 2015 Feb;83(2):133-5. doi: 10.1016/j.wneu.2014.08.031. Epub 2014 Aug 19. PubMed PMID: 25153284.

Crisi G, Filice S, Pertinhez TA, Ventura E, Servadei F. In vivo and ex vivo magnetic resonance spectroscopy in the characterization of hemangioblastoma cyst fluid. J Comput Assist Tomogr. 2014 Jan-Feb;38(1):29-32. doi: 10.1097/RCT.0b013e3182a9103a. PubMed PMID: 24424553.

Chibbaro S, Champeaux C, Poczos P, Cardarelli M, Di Rocco F, Iaccarino C, Servadei F, Tigan L, Chaussemy D, George B, Froelich S, Kehrli P, Romano A. Anterior trans-frontal endoscopic management of colloid cyst: an effective, safe, and elegant way of treatment. Case series and technical note from a multicenter prospective study. Neurosurg Rev. 2014 Apr;37(2):235-41; discussion 241. doi: 10.1007/s10143-013-0508-4. Epub 2013 Dec 19. PubMed PMID: 24352893.

Stefini R, Esposito G, Zanotti B, Iaccarino C, Fontanella MM, Servadei F. Use of “custom made” porous hydroxyapatite implants for cranioplasty: postoperative analysis of complications in 1549 patients. Surg Neurol Int. 2013;4:12. doi: 10.4103/2152-7806.106290. Epub 2013 Jan 28. PubMed PMID: 23493459; PubMed Central PMCID: PMC3589836.

Iaccarino C, Romano A, Ramponi V, Nasi D, Maggi M, Pascarella R, Ghadirpour R, Servadei F. Entrapment of temporal horn: first case of bilateral occurrence and review of literature. Clin Neurol Neurosurg. 2013 Oct;115(10):2207-12. doi: 10.1016/j.clineuro.2013.06.004. Epub 2013 Jul 11. PubMed PMID: 23850345.

Franco Servadei , MD

According to the WFNS Mission Statement and Purpose, my candidature Programme includes:

Substantial changes to the WFNS Structure such as :

• The President and Officers should be elected for a two-year term and not for four years . These changes will not necessarily be related to/affect the WFNS Congress which can be every two or four years . Voting may take place , as now , at the Interim Meetings and , if necessary , at the World Congresses..
• The Administative Council Meeting should be limited to the members of the Administrative Council . Other officers, such as the Second Vice-Presidents, can take part in the Meetings but cannot partecipate in the voting process. . Honorary Presidents and Past Presidents can participate only if invited for their particular expertise . In my opinion officers of the WFNS should be from different Continents and different Countries with no more than one from any single Institution.
• The WFNS Congresses and Interim Meetings should have a rotation among the different Continental Organisation . The WFNS itself will take care of the rotation list but not of the nomination of the sites for the Congresses which will be left to the decision of the Continental Organisation.
• The WFNS should control the activities of the WFNS Foundation . Full transparency is required regarding the entire process of fund-raising and distribution of resources . The WFNS foundation should be based on the same rules for membership as the WFNS:
• The age limit for the WFNS President, officiers and WFNS Foundation members is 69 years . After the misunderstanding that occurred last year, a complete and clear definition of this age limit is mandatory.
• The number of WFNS Committes is too high (I have counted 37 Committees) . They mainly meet once a year but their scientific production is very limited . Apart from the By-laws Committees (which could also be re-organized) there is a need for fewer Committees with clear targets (e.g. emission of guidelines, organisation of practical courses etc) and a time limit (for producing results ).

Initiatives aimed at disseminating full knowledge and awareness of WFNS activities

• To widen the presence and to enhance the role of the Federation in every corner of the world, using the new tools available for communication and the social media;

• To circulate an electronic Newsletter addressed to the member Societies including update information on activities;

• To facilitate interactive participation and to encourage  discussion groups on clinical cases through a new technological platform;

• To promote learning opportunities and to sustain the efforts of single neurosurgeons intending, on a voluntary basis, to join neurosurgical groups in countries with a very low neurosurgeon:population ratio;

• To organize a greater number of Hands-on Courses and to improve the availability of simulator models for training young neurosurgeons in developing countries;

• To launch the ambitious initiative “Twin member Societies help each other” for the training Programs of young neurosurgeons. A good model of this is the present Project “Africa 100″, which, however,  can be extended to  other  Continents and further implemented. For example, in Myanmar there are 13 neurosurgeons for 54 million inhabitants and many other similar situations can be found all around the world;

7)  The general limits of the WFNS are those of all Associations of Societies: the difficulty of reaching all the individual members of each single Society: this limit could partly be overcome by providing each member Society with regular, periodical and complete information about its activities.

8) The most important task for the WFNS is to make member Societies and single neurosurgeons feel updated, supported and encouraged in their Research and Training Programs and to feel involved,  possibly  ON-LINE,  in the different issues at hand. This would enable informal discussion of scientific and professional concerns with the international neurosurgical community and favour continuous feedback and proposals through the same platforms.

About 5000 SURGICAL OPERATIONs AS FIRST SURGEON IN CRANIAL AND SPINAL SURGERY. 950 OF THEM FROM 2007 ;

the Department of Neurosurgery-Neurotraumatology of University Hospital of Parma and Institute of Scientific Research and Care “ASMN” of Reggio Emilia deals with all emergency and elective neurosurgery like cranial and spine traumas, neuro-oncology, skull base tumors , vascular sugery (both open and endovascular approaces) , spinal cord tumors (with neurophysiological monitoring) , endoscopy both for skull base l and ventricular approaces, complex spinal surgery, neuronavigation, and peripheral nerves surgery

Participation as invited speaker in 45 international meetings, including:

The Congress of American Association of Neurological Surgeons (AANS)

The Congress of Neurological Surgeons (CNS)

The Congress of European Association Neuorological of Societies (EANS)

The Congress of World Federation of Neurological Societies (WFNS)

The ICRAN Neurotrauma Conference

The Neurotrauma Symposium

The Congress of European Society of Intensive Care and Neurology

The Congresess of Neurosurgery Societies of Germany,Spain, Greece,Mexico, Cuba,Iranand India.

32 of these reports have been carried out over the past 10 years.

Invitations as a speaker for continents in last 10 years

America : Mexico, Argentina, USA

Asia-Oceania : Australia, Malesia , Singapore , Taiwan, Japan , Cina,, Corea , Pakistan, India

North Africa- Middle East : Israel , Abu Dhabi , Iran, Egypt , Marocco

Europe : Italy, France, Spain, Portugal, Greece, Hungary, UK, Germany, Austria, Sweden, Denmark, Finland, Russia